calcium alpha-ketoglutarate
Calcium Alpha-Ketoglutarate (Ca-AKG) is a stable salt of alpha-ketoglutarate, a key intermediate in the Krebs cycle that facilitates cellular energy production and amino acid metabolism. It acts as a signaling molecule to regulate epigenetic aging processes and nitrogen balance, making it a primary compound in longevity research for extending healthspan.
Lab Notes — Research Studies
01 Recruitment evaluation of a gerotherapeutic randomized controlled trial testing alpha-ketoglutarate in biologically older, middle-aged adults (ABLE)
This clinical trial investigated the potential for Ca-AKG to act as a geroprotector in middle-aged adults by targeting molecular aging processes.
View Study ((PubMed))02 Calcium alpha-ketoglutarate administration to malnourished hemodialysis patients improves plasma arginine concentrations
One year of Ca-AKG supplementation significantly increased levels of essential amino acids like L-arginine and improved protein metabolism biomarkers.
View Study ((PubMed))03 Long-term treatment with calcium-alpha-ketoglutarate corrects secondary hyperparathyroidism
A 36-month study found that Ca-AKG effectively binds phosphate and normalizes parathyroid hormone levels in patients with metabolic bone issues.
View Study ((PubMed))04 Alpha-ketoglutarate application in hemodialysis patients improves amino acid metabolism
Administration of alpha-ketoglutarate alongside calcium binders helped decrease urea and improve levels of branched-chain ketoacids.
View Study ((PubMed))Formula — Benefits & Dosage
⚗️ Effects
- Healthspan Extension: Research in models suggests a roughly 50% extension in healthspan by delaying the onset of frailty.
- Amino Acid Synthesis: Highly effective at raising plasma concentrations of glutamate and arginine in malnourished populations.
- Epigenetic Stability: Clinical observation showed an average 8-year reduction in biological age over 7 months of use.
- Wound Healing: Used in clinical contexts to improve outcomes for pressure ulcers and skin integrity.
💉 Dosage & Administration
- Longevity Protocol: 1,000 mg (1 gram) per day is the standard dose used in biological age reversal studies.
- Clinical Phosphate Binding: Higher doses up to 4.5 grams per day have been used under medical supervision for kidney-related hyperphosphatemia.
- Arginine Support: 3.6 grams of AKG (as Ca-AKG) is used to significantly modulate plasma amino acid profiles.
⚠️ Side Effects
- Digestive Discomfort: Some users mention minor gut discomfort if taken on an empty stomach in high doses.
- Calcium Loading: Excess intake may contribute to high calcium levels if not balanced with Vitamin K2 and Magnesium.
- Hypercalcemia Risk: In renal patients, serum calcium must be monitored as Ca-AKG can increase calcium absorption.
📦 Availability & Sourcing
- Sourcing: Widely available in the US and Europe as an over-the-counter dietary supplement, often marketed under the brand Rejuvant.
- Legal Status: Unrestricted as a nutraceutical; commonly categorized alongside other 'geroprotectors' in the biohacking community.
Reaction Log — User Experiences
Users and longevity enthusiasts generally view Ca-AKG as a elite performance and anti-aging supplement, frequently citing its inclusion in record-breaking rejuvenation protocols.
Synthesis — Related Compounds
⚠️ IMPORTANT DISCLAIMER
This information is for educational and research purposes only. calcium alpha-ketoglutarate may not be approved for human use. Always consult a qualified healthcare professional before using any supplements or research compounds. We do not guarantee accuracy or completeness of information presented.