hypericin
Hypericin is a naphthodianthrone compound found in St. John's Wort (Hypericum perforatum), primarily used for treating mild to moderate depression. It acts as a weak MAO-A and MAO-B inhibitor, has affinity for sigma receptors, modulates HPA axis function, and antagonizes several receptors including GABA-A/B and benzodiazepine receptors. Often combined with hyperforin, another active constituent that inhibits reuptake of serotonin, dopamine, and norepinephrine.
Lab Notes — Research Studies
01 Effect of Hypericum perforatum (St John's Wort) in Major Depressive Disorder
Clinical trial by the Hypericum Depression Trial Study Group examining the efficacy of St John's Wort extract for treating major depression, comparing it to placebo and standard antidepressants.
View Study ((PubMed))02 St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties
Comprehensive review of hypericin and hyperforin chemistry, mechanisms of action including MAO inhibition and receptor interactions, and clinical applications for depression treatment.
View Study ((PubMed))03 St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature
Extensive review covering pharmacological mechanisms, potential toxicity concerns including photosensitivity, and clinical efficacy data for depression and anxiety disorders.
View Study ((PubMed))Formula — Benefits & Dosage
⚗️ Effects
- Delayed Onset: Benefits typically require 2-4 weeks of consistent daily use before noticeable effects appear, similar to prescription antidepressants
- Extract Variability: Effectiveness varies significantly between brands and extract types, with hypericin-standardized (0.3%) and hyperforin-standardized (2%) formulations showing different results
- Mild to Moderate Cases: Most effective for mild to moderate depression and anxiety; users with severe depression report limited benefits
- Individual Response: Highly variable individual responses, with some users experiencing significant benefits while others report minimal or no effects
💉 Dosage & Administration
- Standard Daily Dose: 900mg per day divided into three 300mg doses, standardized to 0.3% hypericin, is the most commonly referenced effective dosage
- Higher Doses: Some users report better results with 1800mg daily (in divided doses), though this increases side effect risk
- Hyperforin Formulations: Perika and similar brands standardized to 2% hyperforin (6mg) are mentioned as potentially safer alternatives regarding eye concerns
- Consistency Required: Daily consistent dosing for at least 2-4 weeks is necessary before assessing effectiveness
⚠️ Side Effects
- Photosensitivity and Eye Concerns: Major worry about hypericin causing retinal damage or cataracts with light exposure, though risk with hyperforin formulations appears lower
- Drug Interactions: Significant interactions with medications including SSRIs, birth control, and various prescription drugs due to effects on liver enzymes
- Digestive Issues: Some users report appetite changes, nausea, or gastrointestinal discomfort, particularly when starting
- Cognitive Effects: Reports of brain fog, restlessness, impatience, or difficulty focusing in some users, especially in early weeks
📦 Availability & Sourcing
- Widely Available OTC: Readily available over-the-counter at health stores and online retailers without prescription
- Brand Quality Varies: quality brands, quality brands (Perika), and standardized pharmaceutical-grade extracts are most commonly recommended for consistent potency
- Standardization Important: Users emphasize choosing products standardized to either 0.3% hypericin or 2% hyperforin for reliable effects
Reaction Log — User Experiences
Users report moderate effectiveness for mild to moderate depression and anxiety, with benefits appearing after 2-4 weeks of consistent use. However, concerns about eye damage from hypericin, drug interactions, and inconsistent results between brands create hesitation, leading to genuinely mixed experiences.
Synthesis — Related Compounds
⚠️ IMPORTANT DISCLAIMER
This information is for educational and research purposes only. hypericin may not be approved for human use. Always consult a qualified healthcare professional before using any supplements or research compounds. We do not guarantee accuracy or completeness of information presented.