ll-37
LL-37 is a human antimicrobial peptide (cathelicidin) that plays a crucial role in innate immunity. It has antibacterial, antiviral, and antifungal properties, and also modulates inflammation and wound healing.
Lab Notes — Research Studies
01 The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics
LL-37 creates a narrow tetrameric channel in bacterial cell walls, causing cell wall damage and cell death.
View Study ((Springer Nature))02 Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice
LL-37 improves survival in septic mice by suppressing macrophage pyroptosis and inflammatory cytokine production.
View Study ((Oxford Academic))03 LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity
LL-37 exhibits broad-spectrum antibiotic activity with chemotactic and immunomodulatory properties.
View Study ((ScienceDirect))04 The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs
LL-37 and its fragments demonstrate potential anticancer effects across various cancer cell lines.
View Study ((Frontiers))05 A comprehensive summary of LL-37, the factotum human cathelicidin peptide
LL-37 exhibits pleiotropic antibacterial, antifungal, antiviral, and chemotactic properties with immunostimulatory effects.
View Study ((ScienceDirect))06 The human cathelicidin peptide LL-37 inhibits pancreatic cancer growth by suppressing autophagy and reprogramming of the tumor immune microenvironment
LL-37 inhibits pancreatic cancer growth through autophagy suppression and immune microenvironment reprogramming.
View Study ((Frontiers))Formula — Benefits & Dosage
⚗️ Effects
- Broad Spectrum: Active against many types of pathogens.
- Immune Support: May help with chronic or recurring infections.
- Synergy: Sometimes combined with other antimicrobial peptides.
💉 Dosage & Administration
- Typical Range: 100-500mcg subcutaneously.
- Frequency: Often daily or every other day during acute use.
- Duration: Cycles vary depending on indication.
⚠️ Side Effects
- Injection Site Reactions: Redness and irritation common.
- Inflammatory Response: May initially increase inflammation.
- Limited Safety Data: Long-term use not well studied.
📦 Availability & Sourcing
- Research Chemical: Available from peptide suppliers.
- Specialized Use: Not as common as other peptides.
- Quality Critical: Purity important for injectable use.
Reaction Log — User Experiences
Used primarily for immune support and infection management. Users with chronic infections report benefits. More common in clinical and biohacking contexts.
Synthesis — Related Compounds
⚠️ IMPORTANT DISCLAIMER
This information is for educational and research purposes only. ll-37 may not be approved for human use. Always consult a qualified healthcare professional before using any supplements or research compounds. We do not guarantee accuracy or completeness of information presented.