myricetin
Myricetin is a flavonoid compound found in berries, red wine, and various fruits and vegetables that exhibits potent antioxidant and anti-inflammatory properties. It works through multiple mechanisms including inhibition of various enzymes (CYP2C9, CYP2D6, cathepsin K, gastric H+/K+-ATPase), modulation of PI3K/AKT and Nrf2 signaling pathways, and enhancement of neurotrophic factors like BDNF and NGF. Research indicates potential benefits for metabolic disorders, cognitive function, cancer prevention, and inflammatory conditions.
Lab Notes — Research Studies
01 Efficacy of Myricetin Supplementation on Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis of In Vivo Mice Studies
Meta-analysis of mouse studies showed myricetin supplementation significantly improved glucose metabolism and lipid profiles in metabolic disease models, demonstrating potential anti-diabetic effects through insulin sensitivity enhancement.
View Study ((PubMed))02 Myricetin improves cognitive function in SAMP8 mice and upregulates brain-derived neurotrophic factor and nerve growth factor
Daily myricetin intake normalized cognitive dysfunction in aging mouse models by increasing BDNF and NGF levels and enhancing CREB phosphorylation, suggesting neuroprotective benefits.
View Study ((PubMed))03 Therapeutic potential of multifunctional myricetin for treatment of type 2 diabetes mellitus
Review demonstrates myricetin's multiple anti-diabetic mechanisms including inhibiting glucose absorption, enhancing insulin secretion as a possible GLP-1 receptor agonist, and protecting endothelial cells from hyperglycemia-induced oxidative stress.
View Study ((PubMed))04 Hypoglycemic activity and mechanisms of myricetin
Four-week administration of myricetin (50-200 mg/kg) in diabetic rats dose-dependently reduced blood glucose and insulin while protecting pancreatic tissue from apoptosis through regulation of Bax and Bcl-2 genes.
View Study ((PubMed))05 Unveiling myricetin's pharmacological potency: A comprehensive exploration of the molecular pathways with special focus on PI3K/AKT and Nrf2 signaling
Comprehensive review revealed myricetin's therapeutic effects operate through PI3K/AKT and Nrf2 pathways, demonstrating antioxidant, anticancer, anti-inflammatory, antiviral, antidiabetic, and neuroprotective properties.
View Study ((PubMed))06 Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications
Systematic review of preclinical evidence shows myricetin exhibits multiple bioactive effects including anti-inflammatory, antioxidant, anticancer, and metabolic benefits, supporting its potential as a therapeutic supplement.
View Study ((PubMed))07 Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals
Review highlights myricetin's anticancer properties through multiple mechanisms, suggesting strong potential for development as an anticancer nutraceutical with applications in preventing and managing various cancer types.
View Study ((PubMed))08 Myricetin ameliorates the symptoms of collagen-induced arthritis in mice by inhibiting cathepsin K activity
Myricetin (25 mg/kg daily) directly inhibited cathepsin K enzyme activity and demonstrated positive effects in reducing arthritic symptoms in mouse models of collagen-induced arthritis.
View Study ((PubMed))Formula — Benefits & Dosage
⚗️ Effects
- Dose-Response Relationship: Studies show effectiveness at 50-200 mg/kg in animal models with dose-dependent improvements
- Multiple Mechanisms: Works through various pathways including enzyme inhibition, gene expression modulation, and receptor activation
- Metabolic Benefits: Meta-analysis confirms significant effects on glucose and lipid profiles in metabolic disease models
- Neuroprotection: Demonstrated cognitive improvements through neurotrophic factor enhancement and CREB phosphorylation
💉 Dosage & Administration
- Animal Studies: Most effective doses range from 25-200 mg/kg body weight in rodent models
- Human Equivalence: Direct human dosing not well established; extrapolation from animal studies suggests moderate supplementation
- COMT Inhibition: Users mention interest in myricetin for COMT inhibition but specific effective doses not reported
- Supplement Combinations: Often included in multi-supplement regimens but isolated dosing recommendations limited
⚠️ Side Effects
- Drug Interactions: Inhibits CYP2C9, CYP2D6, and P-glycoprotein, potentially affecting metabolism of various medications
- Bioavailability Effects: May significantly increase bioavailability of co-administered drugs like carvedilol by 52-85%
- Digestive Concerns: Some users report potential constipation when combined with other supplements in complex regimens
- Safety Profile: Generally well-tolerated in studies but long-term human safety data limited
📦 Availability & Sourcing
- Natural Sources: Found in berries, red wine, fruits, and vegetables; available as dietary supplement
- Supplement Forms: Available as isolated compound or in combination products with other flavonoids
- Research Status: Extensively studied in preclinical models but human clinical trial data remains limited
Reaction Log — User Experiences
Limited User feedback exists about myricetin specifically, with most mentions occurring in broader supplement discussions. Users show interest in it as a COMT inhibitor and include it in complex supplement regimens, but there is insufficient user feedback to establish clear consensus on effectiveness or side effects.
Synthesis — Related Compounds
⚠️ IMPORTANT DISCLAIMER
This information is for educational and research purposes only. myricetin may not be approved for human use. Always consult a qualified healthcare professional before using any supplements or research compounds. We do not guarantee accuracy or completeness of information presented.