nobiletin
Nobiletin is a polymethoxylated flavonoid extracted from citrus peels that has demonstrated neuroprotective, anti-inflammatory, and metabolic benefits in preclinical studies. It works by modulating circadian clock proteins, reducing amyloid-beta accumulation, enhancing cAMP/PKA signaling, and providing antioxidant protection. Primary research focuses on cognitive enhancement, memory improvement, and potential therapeutic applications in neurodegenerative diseases.
Lab Notes — Research Studies
01 Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD)
Nobiletin reduced soluble amyloid-beta oligomers and improved cognitive impairment in a triple transgenic Alzheimer's mouse model, suggesting potential therapeutic benefits for memory and cognitive function.
View Study ((PubMed))02 Nobiletin, a citrus flavonoid, improves memory impairment and Abeta pathology in a transgenic mouse model of Alzheimer's disease
Nobiletin enhanced cAMP/PKA/CREB signaling and reduced amyloid-beta pathology in transgenic mice, demonstrating memory-improving effects through multiple molecular pathways.
View Study ((PubMed))03 Nobiletin prevents amyloid β1-40-induced cognitive impairment via inhibition of neuroinflammation and oxidative/nitrosative stress
Nobiletin protected against amyloid-beta induced cognitive deficits by reducing neuroinflammation and oxidative stress, supporting its anti-inflammatory and antioxidant mechanisms in the brain.
View Study ((PubMed))Formula — Benefits & Dosage
⚗️ Effects
- Animal Model Success: Consistently shows cognitive benefits in transgenic mouse models of Alzheimer's disease with measurable reduction in pathological markers
- Multiple Mechanisms: Works through various pathways including cAMP/PKA signaling, antioxidant activity, and circadian clock modulation for comprehensive neuroprotection
- Blood-Brain Barrier: High lipid solubility and bioavailability allow effective penetration into the central nervous system
- Human Evidence Gap: While preclinical data is promising, limited human clinical trials exist to confirm effectiveness in people
💉 Dosage & Administration
- Research Doses: Animal studies typically use doses ranging from 10-50 mg/kg body weight, though human equivalent doses remain to be established
- Bioavailability: High fat solubility suggests potential benefits from taking with fatty meals to enhance absorption
- Chronic Administration: Studies show benefits with sustained daily dosing rather than acute single-dose effects
- Safety Profile: Preclinical studies indicate low toxicity even at higher doses, though long-term human safety data is limited
⚠️ Side Effects
- Minimal Reported: Preclinical studies characterize nobiletin as having low toxicity with few adverse effects observed
- Unknown Human Profile: Lack of extensive human trials means side effect profile in people remains largely undocumented
- Potential Drug Interactions: As a flavonoid, may interact with cytochrome P450 enzymes affecting medication metabolism
- Long-term Safety Unknown: Insufficient data on effects of prolonged human supplementation
📦 Availability & Sourcing
- Citrus Source: Naturally found in citrus fruit peels, particularly tangerine and sweet orange peels
- Supplement Form: Available as isolated compound supplements though less common than other nootropics
- Research Chemical: Often obtained through research chemical suppliers due to limited mainstream supplement availability
Reaction Log — User Experiences
User experiences are limited with minimal User feedback available. The compound shows strong preclinical evidence but lacks substantial real-world user feedback to establish clear sentiment patterns.
Synthesis — Related Compounds
⚠️ IMPORTANT DISCLAIMER
This information is for educational and research purposes only. nobiletin may not be approved for human use. Always consult a qualified healthcare professional before using any supplements or research compounds. We do not guarantee accuracy or completeness of information presented.