nsi-189
NSI-189 is an experimental nootropic compound that stimulates neurogenesis in the hippocampus. Originally developed for depression, it may enhance memory, cognition, and emotional regulation by promoting new neuron growth.
Lab Notes — Research Studies
01 The neurogenic compound, NSI-189 phosphate: a novel multi-domain treatment capable of pro-cognitive and antidepressant effects
Examines NSI-189's ability to stimulate brain cell growth with potential benefits for depression and cognitive disorders.
View Study ((PubMed))02 Enhancement of synaptic plasticity and reversal of impairments in motor and cognitive functions in a mouse model of Angelman Syndrome by NSI-189
Demonstrates NSI-189 enhanced long-term potentiation and reversed cognitive and motor function impairments in mouse models of Angelman Syndrome.
View Study ((ScienceDirect))03 A phase 2, double-blind, placebo-controlled study of NSI-189 phosphate for major depressive disorder
Found NSI-189 did not significantly reduce depression versus placebo, though the 40 mg dose improved secondary measures.
View Study ((Massachusetts General Hospital))04 A Phase 1B, randomized, double blind, placebo controlled study of NSI-189 phosphate in depressed patients
Early-phase testing showed NSI-189 produced promising reductions in depressive and cognitive symptoms with no serious adverse effects.
View Study ((Massachusetts General Hospital))05 NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats
Oral NSI-189 significantly improved motor and neurological function, promoted brain remodeling in ischemic stroke models.
View Study ((Department of Neurosurgery))Formula — Benefits & Dosage
⚗️ Effects
- Individual Variation: Highly variable response among users.
- Gradual Effects: Benefits may take weeks to manifest.
- Unique Mechanism: Different from traditional nootropics.
💉 Dosage & Administration
- Typical Range: 40-80mg daily, often divided.
- Clinical Trials: Used 40mg once or twice daily.
- Duration: Often used in multi-week courses.
⚠️ Side Effects
- Headaches: Some users report headaches.
- Emotional Processing: Initial emotional changes possible.
- Unknown Long-Term: Safety profile not fully characterized.
- Generally Tolerable: Most side effects mild.
📦 Availability & Sourcing
- Research Chemical: Available from select suppliers.
- Limited Availability: Not as widely stocked as other nootropics.
- Experimental: Still in development; not approved for any use.
Reaction Log — User Experiences
Users report improved mood, memory, and spatial awareness. Some describe profound positive changes while others notice minimal effects. Long-term safety unknown.
Synthesis — Related Compounds
⚠️ IMPORTANT DISCLAIMER
This information is for educational and research purposes only. nsi-189 may not be approved for human use. Always consult a qualified healthcare professional before using any supplements or research compounds. We do not guarantee accuracy or completeness of information presented.