pterostilbene
Pterostilbene is a naturally occurring polyphenolic compound, primarily found in blueberries and grapes, that is a dimethylated analog of resveratrol with superior bioavailability. It functions as a potent antioxidant, anti-inflammatory agent, and sirtuin activator, with effects on cellular metabolism, epigenetic regulation, and NAD+ pathways. Research suggests applications in metabolic health, cognitive function, longevity, and cancer prevention.
Lab Notes — Research Studies
01 Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions
Review examining NAD+ precursor supplementation including nicotinamide riboside co-administered with pterostilbene, finding these compounds are common candidates for improving physiologic function in aging and age-related diseases.
View Study ((PubMed))02 Pterostilbene Targets Hallmarks of Aging in the Gene Expression Landscape in Blood of Healthy Rats
Pterostilbene supplementation in healthy rats modulated gene expression related to key aging hallmarks, suggesting anti-aging effects at the molecular level through epigenetic mechanisms.
View Study ((PubMed))03 A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals
Clinical trial examining NR and pterostilbene supplementation effects on muscle regeneration and stem cell function in elderly individuals following muscle injury.
View Study ((PubMed))04 Pterostilbene, a dimethylated analog of resveratrol, promotes energy metabolism in obese rats
Study found pterostilbene significantly suppressed abdominal fat accumulation, increased oxygen consumption and energy expenditure, and promoted fat metabolism over carbohydrate metabolism in obese rats.
View Study ((PubMed))05 Pterostilbene-induced changes in gut microbiota composition in relation to obesity
Pterostilbene supplementation induced beneficial changes in gut microbiota composition associated with improvements in obesity-related metabolic parameters.
View Study ((PubMed))06 AMPK-Dependent Epigenetic Regulation of Metabolism Mediates the Anti-Cancer Action of Pterostilbene in Hepatocellular Carcinoma
Pterostilbene demonstrated anti-cancer effects in hepatocellular carcinoma through AMPK-dependent epigenetic regulation of metabolism, suggesting potential therapeutic applications.
View Study ((PubMed))07 Dietary Pterostilbene for MTA1-Targeted Interception in High-Risk Premalignant Prostate Cancer
Dietary pterostilbene showed promise for cancer prevention in high-risk premalignant prostate cancer through targeted molecular mechanisms, supporting its potential for nutritional intervention.
View Study ((PubMed))08 Pterostilbene enhances reproductive outcomes and oocyte quality in aged mice without adverse effects
Long-term pterostilbene supplementation improved reproductive outcomes, increased implantation and live birth rates in aged mice, and enhanced oocyte quality without affecting estrous cycles or offspring health.
View Study ((PubMed))Formula — Benefits & Dosage
⚗️ Effects
- Synergistic Effects: Most effective when combined with NAD+ boosters like NR or NMN, with users reporting the combination works better than either alone
- Bioavailability Advantage: Users choose pterostilbene over resveratrol due to its superior absorption and lipophilicity, noting it's more cost-effective despite higher price
- Long-term Benefits: Users report sustained benefits over months to years, particularly for anti-aging goals, with some showing measurable improvements in biomarkers
- Individual Variation: Effectiveness varies significantly between users, with some reporting dramatic results while others notice minimal changes
💉 Dosage & Administration
- Standard Dose: Most commonly used at 50-150mg daily, often as part of combination products with NR
- Timing: Typically taken in the morning on empty stomach or with breakfast as part of longevity stacks
- Cycling: Some users cycle pterostilbene as part of senolytic protocols rather than taking daily
- Stack Integration: Usually combined with 250-300mg NR, quercetin, fisetin, and other longevity compounds
⚠️ Side Effects
- Minimal Reported: Very few direct side effects attributed to pterostilbene specifically in user reports
- Stack Interactions: Users occasionally report difficulty determining which compound in complex stacks causes effects or side effects
- Cost Concerns: High cost is the main complaint, with users seeking more affordable alternatives or questioning cost-effectiveness
- Limited Standalone Data: Most users take it in combination, making it difficult to isolate specific side effects
📦 Availability & Sourcing
- Commercial Products: Available from supplement companies, often combined with NR in branded products like Basis and Tru Niagen
- Quality Brands: Users prefer brands that provide third-party testing for purity and potency verification
- Food Sources: Naturally found in blueberries, though supplemental doses are much higher than dietary intake
Reaction Log — User Experiences
Users report pterostilbene as an effective longevity and anti-aging supplement, particularly when combined with NAD+ precursors like NR. Most users taking it as part of comprehensive stacks report positive results for energy, cognitive function, and overall health markers, though it's rarely used alone.
Synthesis — Related Compounds
⚠️ IMPORTANT DISCLAIMER
This information is for educational and research purposes only. pterostilbene may not be approved for human use. Always consult a qualified healthcare professional before using any supplements or research compounds. We do not guarantee accuracy or completeness of information presented.