wogonin
Wogonin is a natural flavonoid compound extracted from Scutellaria baicalensis (Chinese skullcap) and related species. It functions primarily through anti-inflammatory, anti-oxidative, and anti-cancer mechanisms, including modulation of MAPK signaling pathways, inhibition of COX-2 expression, and induction of ferroptosis in cancer cells. Research suggests potential applications in cancer treatment, pulmonary conditions, and inflammatory diseases.
Lab Notes â Research Studies
01 Wogonin attenuates septic cardiomyopathy by suppressing ALOX15-mediated ferroptosis
Wogonin protected against septic cardiomyopathy in mice by directly binding to and inhibiting ALOX15, preventing cardiomyocyte ferroptosis and improving cardiac function. The cardioprotective effects were mediated through suppression of ALOX15-initiated ferroptosis.
View Study ((PubMed))02 Wogonin Attenuates Bleomycin-Induced Pulmonary Fibrosis and Oxidative Stress Injury via the MAPK Signaling Pathway
Wogonin significantly reduced pulmonary fibrosis and oxidative stress in a rat model by modulating the MAPK pathway, showing potential as a therapeutic agent for idiopathic pulmonary fibrosis.
View Study ((PubMed))03 Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells
Wogonin inhibited PMA-induced COX-2 expression in lung cancer cells at the transcriptional level through the MEK1/2 pathway and AP-1 activity, demonstrating anti-inflammatory and anti-cancer properties.
View Study ((PubMed))04 Antiproliferative Wnt inhibitor wogonin prevents eryptosis following ionophoric challenge, hyperosmotic shock, oxidative stress, and metabolic deprivation
Wogonin protected red blood cells from premature death (eryptosis) under various stress conditions including calcium overload and oxidative stress, suggesting potential in preventing chemotherapy-related anemia.
View Study ((PubMed))05 Detection of baicalin metabolites baicalein and oroxylin-a in mouse pancreas and pancreatic xenografts
Study demonstrated that baicalin from Scutellaria baicalensis undergoes significant methylation to oroxylin A during absorption, with substantial amounts detected in pancreatic tissue and tumors, showing tissue-specific distribution patterns.
View Study ((PubMed))06 Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products
Analysis of Scutellaria species found significant variations in wogonin and baicalin content between roots and aerial parts, with roots containing substantially higher levels of active flavonoids.
View Study ((PubMed))Formula â Benefits & Dosage
âïļ Effects
- Cancer Applications: Shows promising results in preclinical studies for pancreatic and lung cancer through ferroptosis induction and PI3K/AKT pathway modulation
- Pulmonary Conditions: Demonstrates effectiveness in reducing pulmonary fibrosis and inflammation in animal models
- Cardiac Protection: Provides significant protection against septic cardiomyopathy in experimental settings
- Limited Human Data: Most evidence comes from in vitro and animal studies; clinical human trials are lacking
ð Dosage & Administration
- Animal Studies: Doses of 20-60 mg/kg administered intraperitoneally in mouse models showed cardioprotective and anti-fibrotic effects
- Cell Culture: Concentrations of 50-100 ΞM used in cancer cell studies to induce ferroptosis and inhibit proliferation
- Human Dosing: No standardized human dosing guidelines established; typically consumed as part of Scutellaria baicalensis extracts in traditional medicine
- Bioavailability: Undergoes significant methylation to oroxylin A during absorption, affecting tissue distribution and metabolite activity
â ïļ Side Effects
- Limited Safety Data: Few reported side effects in research studies, but long-term human safety data is minimal
- Interaction Potential: As a COX-2 inhibitor and MAPK modulator, may interact with medications affecting these pathways
- Metabolic Considerations: Converts to oroxylin A metabolite which may have different activity profile than parent compound
- Red Blood Cell Effects: While protective against eryptosis in some conditions, effects on normal red blood cell function require further study
ðĶ Availability & Sourcing
- Herbal Sources: Available primarily through Scutellaria baicalensis (Chinese skullcap) root extracts and supplements
- Standardization Issues: Content varies significantly between products and plant parts (roots vs. aerial parts), with roots containing higher concentrations
- Research Compounds: Pure wogonin available as research chemical but not commonly sold as standalone dietary supplement
Reaction Log â User Experiences
Limited direct user experiences with wogonin as a standalone supplement. Most User feedback discussions focus on other compounds or broader herbal formulations containing Scutellaria species, with minimal specific feedback on wogonin's effects or tolerability.
Synthesis â Related Compounds
â ïļ IMPORTANT DISCLAIMER
This information is for educational and research purposes only. wogonin may not be approved for human use. Always consult a qualified healthcare professional before using any supplements or research compounds. We do not guarantee accuracy or completeness of information presented.