b7-33
B7-33 is a synthetic, single-chain peptidomimetic agonist of the relaxin family peptide receptor 1 (RXFP1), derived from the B-chain of human gene-2 relaxin. It is designed to replicate the vasoprotective and anti-fibrotic effects of native relaxin while being more cost-effective to produce and possessing improved pharmacological properties.
Lab Notes — Research Studies
01 B7-33, a Functionally Selective Relaxin Receptor 1 Agonist, Attenuates Myocardial Infarction-Related Adverse Cardiac Remodeling in Mice
This study found that B7-33 reduces heart damage and scarring after a heart attack by activating specific protective pathways without the side effects of traditional relaxin treatments.
View Study ((PubMed))02 B7-33 replicates the vasoprotective functions of human gene-2 relaxin
Research demonstrates that B7-33 effectively mimics the vascular benefits of human relaxin, promoting blood vessel health and reducing systemic vascular resistance.
View Study ((PubMed))Formula — Benefits & Dosage
⚗️ Effects
- Cardiac Health: Highly effective in animal models for preventing adverse remodeling after myocardial infarction.
- Vascular Protection: Successfully replicates the beneficial effects of serelaxin on endothelial function.
- Targeted Activation: Shows functional selectivity for RXFP1, minimizing off-target signaling pathways.
💉 Dosage & Administration
- Research Dosing: Animal studies often utilize weight-based dosing; human anecdotal ranges typically fall between 1-5mg daily.
- Frequency: Due to its peptide nature, it is typically administered via subcutaneous injection daily or every other day.
- Loading Phase: Some users suggest a short high-dose period to achieve steady state, though this is not clinically validated.
⚠️ Side Effects
- Blood Pressure Drops: Potential for hypotension due to its potent vasodilatory properties.
- Injection Site Reaction: Possible redness, itching, or swelling at the site of administration.
- Hypoglycemia: Minimal reports suggest potential interactions with glucose metabolism in sensitive users.
📦 Availability & Sourcing
- Legal Status: Currently sold as a 'research chemical' and not approved by the FDA for human consumption.
- Sourcing: Primarily available through specialized peptide supply companies and compounding pharmacies.
Reaction Log — User Experiences
User interest is high due to its anti-fibrotic potential and cardiovascular benefits, though it is primarily discussed in specialized peptide and biohacking circles rather than general supplement forums.
Synthesis — Related Compounds
⚠️ IMPORTANT DISCLAIMER
This information is for educational and research purposes only. b7-33 may not be approved for human use. Always consult a qualified healthcare professional before using any supplements or research compounds. We do not guarantee accuracy or completeness of information presented.