bms-564929
BMS-564929 is a potent, orally active nonsteroidal selective androgen receptor modulator (SARM) designed to treat age-related declines in muscle mass and physical function. It works by acting as a high-affinity agonist for androgen receptors in muscle and bone while maintaining significant tissue selectivity to avoid stimulating the prostate.
Lab Notes — Research Studies
01 Ockham's Razor and Selective Androgen Receptor Modulators (SARMs): Are We Overlooking the Role of 5α-Reductase?
This study explains how SARMs like BMS-564929 achieve selectivity because they are not substrates for 5α-reductase, preventing the localized amplification of androgenic effects in the prostate.
View Study ((PubMed))02 Selective Androgen Receptor Modulators (SARMs) as Function Promoting Therapies
Research indicates that nonsteroidal SARMs act as full agonists in muscle and bone while acting as only partial agonists in the prostate, offering a safer profile than traditional steroids.
View Study ((PubMed))03 Selective androgen receptor modulators: the future of androgen therapy?
Clinical analysis suggests that SARMs represent a promising class of drugs for treating muscle wasting and hypogonadism with significantly reduced side effects compared to testosterone.
View Study ((PubMed))Formula — Benefits & Dosage
⚗️ Effects
- High Potency: In preclinical models, it has shown to be more potent than testosterone in stimulating muscle growth per milligram
- Tissue Selectivity: Highly effective at separating muscle-building benefits from undesirable androgenic side effects
- Oral Bioavailability: Unlike many traditional androgens, it is designed for effective oral administration
💉 Dosage & Administration
- Clinical Trials: Doses in human research have been evaluated at very low levels (e.g., 0.1 mg to 1 mg) due to its high potency
- Preclinical Range: Animal studies utilized doses ranging from 0.03 to 3 mg/kg to determine anabolic thresholds
- Experimental Use: Users often caution that due to high binding affinity, 'less is more' to maintain selectivity
⚠️ Side Effects
- Hormonal Suppression: Like all SARMs, it may suppress natural testosterone production at higher dosages
- Lipid Changes: Potential reduction in HDL (good) cholesterol, a common trait across the SARM class
- SHBG Reduction: Likely to cause a decrease in Sex Hormone-Binding Globulin levels during active use
📦 Availability & Sourcing
- Legal Status: Currently not FDA-approved for human use and prohibited by WADA for competitive athletes
- Research Only: Primarily available through chemical supply companies for laboratory research purposes
Reaction Log — User Experiences
While clinical research is highly optimistic about its tissue selectivity, user data for this specific compound is sparse compared to more common SARMs, leading to a cautious but generally curious sentiment regarding its muscle-building potential.
Synthesis — Related Compounds
⚠️ IMPORTANT DISCLAIMER
This information is for educational and research purposes only. bms-564929 may not be approved for human use. Always consult a qualified healthcare professional before using any supplements or research compounds. We do not guarantee accuracy or completeness of information presented.