glpg-0492
GLPG-0492 is a non-steroidal selective androgen receptor modulator (SARM) designed to bind to the androgen receptor with high affinity while exhibiting tissue-selective anabolic activity. It was originally developed to treat muscle-wasting conditions and muscular dystrophy by stimulating muscle growth and Improving performance with reduced androgenic effects on reproductive organs.
Lab Notes — Research Studies
01 Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization
This study found that GLPG-0492 effectively prevented muscle mass loss and preserved muscle fiber size in mice during periods of inactivity.
View Study ((PubMed))02 GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy
Research demonstrated that GLPG-0492 improved diaphragm and limb muscle function and increased running performance in models of Duchenne muscular dystrophy.
View Study ((PubMed))03 Comparison of the three SARMs RAD-140, GLPG0492 and GSK-2881078 in two different in vitro bioassays, and in an in silico androgen receptor binding assay
This comparative analysis confirmed GLPG-0492's strong androgenic potential in prostate cells and provided molecular modeling of its binding to the androgen receptor.
View Study ((PubMed))Formula — Benefits & Dosage
⚗️ Effects
- Anabolic Selectivity: Demonstrates a high ratio of muscle-to-prostate activity, reducing the risk of androgenic side effects
- Recovery Speed: Users report faster recovery times between training sessions and reduced muscle soreness
- Mild Potency: Often considered less 'explosive' for mass building than LGD-4033 but easier to manage in terms of side effects
💉 Dosage & Administration
- Common Range: Most anecdotal reports suggest a daily total of 5mg to 15mg taken once per day
- Starting Dose: Users often recommend starting at 5mg to assess individual tolerance before increasing
- Cycle Length: Standard cycles typically last 8 to 12 weeks followed by appropriate post-cycle therapy
⚠️ Side Effects
- Hormonal Suppression: Like most SARMs, it can cause a temporary reduction in natural testosterone levels, especially at higher doses
- Lipid Changes: Potential for a slight reduction in HDL (good cholesterol) during the cycle
- Liver Enzymes: Rare reports of mild elevations in liver enzymes, though generally considered less hepatotoxic than oral steroids
📦 Availability & Sourcing
- Sourcing Difficulty: Less commonly available than mainstream SARMs like Ostarine, often requiring specialized research chemical suppliers
- WADA Status: Explicitly listed as a prohibited substance in competitive sports under the S1.2 Anabolic Agents category
- Research Status: Development appears to have stalled in clinical phases, leaving it primarily in the 'research chemical' market
Reaction Log — User Experiences
Users generally view GLPG-0492 as an effective but 'mild' SARM compared to compounds like RAD-140, with many highlighting its niche status and relative obscurity in the current market.
Synthesis — Related Compounds
⚠️ IMPORTANT DISCLAIMER
This information is for educational and research purposes only. glpg-0492 may not be approved for human use. Always consult a qualified healthcare professional before using any supplements or research compounds. We do not guarantee accuracy or completeness of information presented.