melanotan 1

Melanotan 1 (Afamelanotide) is a synthetic analog of alpha-MSH that stimulates melanin production, causing skin darkening without sun exposure. It's FDA-approved for certain conditions and provides photoprotection for those with light sensitivity.

Purity Rating

65% Positive

Lab Notes — Research Studies

01 In vitro evaluation of Poly(d,l-lactide-co-glycolide) polymer-based implants containing the α-melanocyte stimulating hormone analog, Melanotan-I

Study examined release patterns of Melanotan-I from biodegradable PLGA implants, observing three-phase release.

View Study ((ScienceDirect))

02 An unhealthy glow? A review of melanotan use and associated clinical outcomes

Literature review on Melanotan I and II effects, identifying minor and serious adverse effects including toxidrome and melanoma.

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03 Controlled-Release Delivery System for the α-MSH Analog Melanotan-I Using Poloxamer 407

Researchers developed controlled-release formulations using poloxamer 407 with additives for sustained delivery.

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04 In vitro characterization and in vivo release profile of a poly (d,l-lactide-co-glycolide)-based implant delivery system for the α-MSH analog, Melanotan-I

Researchers developed biodegradable copolymer implants for sustained Melanotan-I delivery, demonstrating steady release over one month.

View Study ((ScienceDirect))

05 Effect of MELANOTAN®, [Nle4, D-Phe7]-α-MSH, on melanin synthesis in humans with MC1R variant alleles

Study found MELANOTAN® significantly increased melanin, especially in those with MC1R genetic variants.

View Study ((ScienceDirect))

Formula — Benefits & Dosage

⚗️ Effects

Slower Than MT-2: Takes longer to produce visible tanning.
More Natural: Produces more gradual, natural-looking results.
FDA Approved: Scenesse approved for erythropoietic protoporphyria.

💉 Dosage & Administration

Typical Range: 0.5-1mg subcutaneously daily.
Loading Phase: Often 1mg daily until desired tan achieved.
Maintenance: Reduced frequency once tan established.

⚠️ Side Effects

Nausea: Common, especially initially.
Facial Flushing: Temporary redness after injection.
Mole Darkening: Existing moles may darken.
Safer Profile: Fewer side effects than MT-2.

📦 Availability & Sourcing

Prescription: FDA-approved as Scenesse for EPP.
Research Chemical: Also available from peptide suppliers.
Higher Cost: Generally more expensive than MT-2.

Reaction Log — User Experiences

Users seeking tanning without sun exposure report good results. Slower acting than MT-2 but considered safer. FDA approval for EPP lends legitimacy.

Synthesis — Related Compounds

A4 AMYLOID BETA → ADIPONECTIN → B7-33 → CARDIOGEN → CARTALAX →

⚠️ IMPORTANT DISCLAIMER

This information is for educational and research purposes only. melanotan 1 may not be approved for human use. Always consult a qualified healthcare professional before using any supplements or research compounds. We do not guarantee accuracy or completeness of information presented.